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4,492 awards
Showing 4451–4492
| Action date | Recipient | Agency | Amount | Description | Sector |
|---|---|---|---|---|---|
| — | MISSISSIPPI STATE UNIVERSITY | Department of Health and Human Services | $33,151,370 | HEAD START AND EARLY HEAD START | social-services |
| — | HEALTHY CONNECTIONS, INC. | Department of Health and Human Services | $33,123,395 | HEALTH CENTER CLUSTER | health |
| — | HEALTH SERVICES KENTUCKY CABINET FOR | Department of Agriculture | $33,120,014 | WIC ADMIN EXPENSES | social-services |
| — | LOS ANGELES COUNTY METROPOLITAN TRANSPORTATION AUTHORITY | Department of Transportation | $33,120,000 | THE PURPOSE OF THE AWARD IS TO ELIMINATE A DANGEROUS AT-GRADE RAIL CROSSING ON THE SECOND BUSIEST RAIL CORRIDOR IN LOS ANGELES COUNTY, CALIFORNIA WHERE MAINLINE PASSENGER AND FREIGHT TRACKS INTERSECT WITH HIGHWAY AND PEDESTRIAN RIGHTS-OF-WAY AT WEST DORAN STREET. THE PROJECT ACTIVITIES WILL INCLUDE THE DESIGN AND CONSTRUCTION OF A GRADE SEPARATION STRUCTURE THAT LINKS THE CITIES OF LOS ANGELES AND GLENDALE. THE CURRENT AT-GRADE CROSSING RUNS EAST-WEST ACROSS THE RAILROAD CORRIDOR. THE OUTCOME OF PROJECT DELIVERY WILL BE DESIGN AND CONSTRUCTION OF A STRUCTURE THAT IS REPLACING THE AT-GRADE CROSSING AT DORAN STREET. THE STRUCTURE WILL GO NORTH AT THE INTERSECTION OF WEST SAN FERNANDO ROAD AND DORAN STREET. THE STRUCTURE WILL EXTEND UNDER THE STATE ROUTE 134 FREEWAY BEFORE CONNECTING TO THE EXISTING FAIRMONT AVENUE BRIDGE, WHICH RUNS EAST-WEST OVER THE RAILROAD CORRIDOR. THE INTENDED BENEFICIARIES OF THE PROJECT WILL PEDESTRIANS, HIGHWAY ROADWAY USERS, AND RAILROAD USERS. THE PROJECT WILL ALSO MEET LOCAL COMMUNITY REQUIREMENTS TO HAVE TWO EMERGENCY RESPONDER POINTS OF ACCESS INTO THE ATWATER VILLAGE NEIGHBORHOOD. | transportation |
| — | WILLIAM MARSH RICE UNIVERSITY | National Science Foundation | $33,116,189 | MID-SCALE RI-2: SAFEINSIGHTS: A NATIONAL RESEARCH INFRASTRUCTURE FOR LARGE-SCALE LEARNING SCIENCE AND ENGINEERING -RESEARCH AND DEVELOPMENT (R&D) PLAYS A PIVOTAL ROLE IN ADVANCING EDUCATION, BUT IT REMAINS DIFFICULT TO CONDUCT LARGE-SCALE RESEARCH THAT YIELDS THE STRONGEST RESULTS FOR STUDENTS AND TEACHERS. SAFEINSIGHTS IS A NATIONAL R&D INFRASTRUCTURE THAT WILL SUPPORT TRANSFORMATIONAL LEARNING RESEARCH BY COORDINATING RESEARCH ACROSS AN INITIAL SET OF MORE THAN A DOZEN SECURELY CONNECTED DIGITAL LEARNING PLATFORMS (DLPS). SAFEINSIGHTS? PRIVACY MODEL KEEPS STUDENT INFORMATION SECURE WHILE ALLOWING RESEARCHERS TO LEVERAGE LEARNING DATA FROM INDIVIDUALS ACROSS MULTIPLE DLPS. SUCH DATA MAY SPAN YEARS AND DIFFERENT EDUCATIONAL INSTITUTIONS, THUS ENABLING RESEARCHERS TO UNDERTAKE LONGITUDINAL STUDIES TO INVESTIGATE, FOR EXAMPLE, HOW CONCEPTUAL UNDERSTANDING DEVELOPS OVER TIME. WITH ITS UNIQUE PRIVACY-PROTECTING APPROACH, ITS LARGE SCALE, AND ITS EMPHASIS ON THE INCLUSION OF STUDENTS, EDUCATORS, AND RESEARCHERS FROM DIVERSE AND REPRESENTATIVE BACKGROUNDS, SAFEINSIGHTS WILL UNLOCK DISCOVERIES ABOUT LEARNING THAT LEAD TO PREDICTORS OF ACADEMIC SUCCESS AND PERSISTENCE. SUCH FINDINGS WILL EVENTUALLY BENEFIT TENS OF MILLIONS OF STUDENTS ACROSS ALL EDUCATIONAL LEVELS IN THE UNITED STATES, AS MORE DLPS ARE CONNECTED. THIS INFRASTRUCTURE IS SUPPORTED BY THE U.S. NATIONAL SCIENCE FOUNDATION (NSF) DIRECTORATE FOR STEM EDUCATION THROUGH THE NSF MID-SCALE RESEARCH INFRASTRUCTURE-2 PROGRAM. SAFEINSIGHTS WILL ENABLE SECURE DATA ANALYSIS AND CONTROLLED RESEARCH STUDIES WITHIN AUTHENTIC LEARNING ENVIRONMENTS AND WILL LEVERAGE LEARNER DATA FROM DIVERSE PLATFORMS TO ADDRESS SCIENTIFIC INQUIRIES WITH GREATER DEPTH AND BREADTH THAN PREVIOUSLY ACHIEVABLE. TO SUPPORT SCIENTISTS AND DATA STEWARDS IN ANSWERING IMPORTANT QUESTIONS ABOUT STEM LEARNING, THIS PIONEERING SCIENTIFIC CYBERINFRASTRUCTURE WILL BUILD SHARED TECHNICAL AND LOGISTICAL CAPABILITIES AS WELL AS SECURE ENCLAVE INFRASTRUCTURE DEPLOYED INSIDE ITS COLLABORATING DLPS. BY ENABLING THE COMBINATION OF INDIVIDUAL OUTCOME AND PERFORMANCE DATA FROM MULTIPLE DLPS WITH ADDITIONAL INFORMATION (E.G., DEMOGRAPHICS, PAST AND CURRENT COURSE PERFORMANCE, ENROLLMENT, AND COMPLETION PATHWAYS) PROVIDED BY STUDENT INFORMATION SYSTEMS (SISS), THE ENVISIONED RESEARCH INFRASTRUCTURE ENABLES EDUCATION RESEARCHERS TO INITIATE LARGE CROSS-SECTIONAL AND LONGITUDINAL STUDIES OF STUDENT LEARNING AND ACHIEVEMENT ACROSS A RANGE OF CONTENT AREAS, CONTEXTS, AND WITH DIFFERENT DEMOGRAPHIC GROUPS. ENCLAVES ENABLE RESEARCHERS TO ASK AND ANSWER EQUITY-CENTERED LEARNING QUESTIONS BECAUSE THEIR ANALYSES CAN ACCOUNT FOR SOCIO-DEMOGRAPHIC VARIABLES IN LARGE-SCALE DATASETS FROM REAL-WORLD LEARNING APPLICATIONS. SAFEINSIGHTS AIMS TO LOWER THE COST AND EXPAND THE SCALE AND SCOPE OF LEARNING RESEARCH, INCREASE ITS AGILITY, ACCELERATE RESEARCH-TO-PRACTICE CONVERSION, AND DEMOCRATIZE ACCESS TO STEM RESEARCH OPPORTUNITIES, PARTICULARLY FOR SCHOLARS FROM UNDERREPRESENTED GROUPS AND MINORITY-SERVING INSTITUTIONS. AS SAFEINSIGHTS UNCOVERS ADVANCED UNDERSTANDINGS OF HUMAN LEARNING, EDUCATORS WILL BE ABLE TO RESPOND THROUGH NEW PERSONALIZED PROGRAMS, PEDAGOGIES, AND POLICIES WITH THE GOAL OF PROVIDING EACH LEARNER WITH THE KNOWLEDGE, SKILLS, AND SUPPORT THEY NEED TO SUCCEED IN TODAY?S CLASSROOM AND TOMORROW?S WORKFORCE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD. | education |
| — | ACCENTURE FEDERAL SERVICES LLC | Department of Energy | $33,072,192 | BLANKET PURCHASE AGREEMENT (BPA) ORDER FOR CHIEF INFORMATION OFFICER (CIO) BUSINESS OPERATIONS SUPPORT SERVICES (CBOSS) 2.0. ORDER LEVEL MATERIALS (OLM) | intelligence |
| — | CHIPPEWA HOUSING AUTHORITY | Department of Housing and Urban Development | $33,050,706 | INDIAN HSG BLOCK GR | housing |
| — | AT&T ENTERPRISES, LLC | Department of Homeland Security | $33,038,714 | FEMA CONTACT CENTER CAPABILITY MODERNIZATION PROGRAM | justice |
| — | HEALTH & HUMAN SVC COMMN TX | Department of Health and Human Services | $33,037,776 | HHSC IS APPLYING FOR THE 988 STATE AND TERRITORY IMPROVEMENT OPPORTUNITY IN ORDER TO IMPROVE TEXAS' RESPONSE TO 988 CONTACTS (INCLUDING CALLS, CHATS, AND TEXTS) ORIGINATING IN TEXAS. - THE TEXAS HEALTH AND HUMAN SERVICES COMMISSION IS APPLYING FOR THE 988 STATE AND TERRITORY IMPROVEMENT PROJECT IN ORDER TO IMPROVE TEXAS' EXISTING 988 CRISIS RESPONSE SYSTEM. HHSC PLANS TO SERVE ALL TEXANS EXPERIENCING MENTAL HEALTH CRISES BY CONNECTING THEM TO A TRAINED CRISIS COUNSELOR WHO CAN ADDRESS THEIR IMMEDIATE NEEDS OR CONNECT THEM TO THE APPROPRIATE RESOURCES. IF AWARDED, HHSC PLANS TO IMPLEMENT A MULTI-FACETED APPROACH TO IMPROVE THE ALREADY EXISTING 988 SERVICES. THIS INCLUDES INCREASING THE IN-STATE ANSWER RATE, IMPROVING THE 988 INFRASTRUCTURE AND THE COORDINATION OF CRISIS RESPONSE SERVICES, IMPROVING 988 SUPPORT FOR HIGH-RISK POPULATIONS, ENSURING COMPREHENSIVE QUALITY ASSURANCE, AND INCREASING AWARENESS OF 988 AND AVAILABLE RESOURCES THROUGHOUT THE STATE. IN ORDER TO ACHIEVE THESE GOALS, HHSC WILL LEVERAGE ITS EXISTING ROBUST CRISIS CONTINUUM AND CONDUCT A COMPREHENSIVE REVIEW OF CURRENT STATEWIDE CAPABILITIES TO INFORM FUTURE DIRECTION DURING THE PROJECT PERIOD WHICH MAY INCLUDE CONTRACTING OR SUBCONTRACTING WITH ENTITIES TO EXPAND IN-STATE 988 SERVICE CAPACITY. HHSC PLANS TO CONTINUE BUILDING ON THE WORK ACCOMPLISHED THROUGH THE 988 STATE AND TERRITORY COOPERATIVE AGREEMENT AWARDED TO HHSC FOR APRIL 2022 THROUGH APRIL 2024. IN JANUARY 2022, TEXAS' IN-STATE ANSWER RATE WAS 45 PERCENT, AND BY APRIL 2023, THE IN-STATE ANSWER RATE INCREASED TO 75 PERCENT. ADDITIONALLY, THROUGH THE WORK OF THE 988 STATE AND TERRITORY COOPERATIVE AGREEMENT, HHSC PURSUED SUBSTANTIAL IMPROVEMENTS IN THE STATEWIDE 988 CRISIS SYSTEM BY EXPANDING PRIMARY AND BACKUP COVERAGE. HHSC WILL CONTINUE TO ALLOCATE FUNDING TO THE FOUR 988 CENTERS PROVIDING PRIMARY COVERAGE AND ONE 988 CENTER PROVIDING BACKUP COVERAGE IN ORDER TO EXPAND WORKFORCE AND REINFORCE SERVICES. HHSC HAS ALREADY BEGUN CREATING A COMMUNICATION STRATEGY PLAN TO ENSURE EDUCATION REGARDING 988 IS ACCESSIBLE TO ALL TEXANS, ESPECIALLY THOSE IN HIGH-RISK POPULATIONS. HHSC IS COMMITTED TO ENHANCING ITS QUALITY ASSURANCE PLAN TO ENSURE THOSE SERVED THROUGH 988 ARE RECEIVING THE BEST SERVICE POSSIBLE. HHSC AND ITS PARTNERS ARE STRONGLY COMMITTED TO WORKING TOWARDS THE MINIMUM REQUIRED IN-STATE ANSWER RATE OF 90 PERCENT BY THE END OF FISCAL YEAR 2026. HHSC WILL CONTRACT WITH PARTNERS TO ENSURE EFFORTS ARE INCREASED IN RECRUITING, HIRING, TRAINING, AND EXPANDING THE BEHAVIORAL HEALTH WORKFORCE IN TEXAS TO UNIFORMLY RESPOND LOCALLY TO PERSONS WHO CALL, CHAT, OR TEXT 988 SERVICES. | health |
| — | THE UNIVERSITY OF CENTRAL FLORIDA BOARD OF TRUSTEES | National Aeronautics and Space Administration | $33,030,845 | LUNAR VULKAN IMAGING AND SPECTROSCOPY EXPLORER (LUNAR-VISE) | aerospace |
| — | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE | Department of Health and Human Services | $33,001,188 | PENN PREVENTION CLINICAL TRIALS UNIT | biotech |
| — | JUNIPER HEALTH, INC. | Department of Health and Human Services | $32,969,946 | HEALTH CENTER CLUSTER | health |
| — | OHIO DEPARTMENT OF JOB & FAMILY SERVICES | Department of Labor | $32,932,150 | PURPOSE: THE PURPOSE OF THE WIOA ADULT GRANTS IS TO SERVE INDIVIDUALS AND HELP EMPLOYERS MEET THEIR WORKFORCE NEEDS. THE WIOA ADULT PROGRAM ENABLES WORKERS TO OBTAIN GOOD JOBS BY PROVIDING THEM WITH CAREER SERVICES LIKE JOB SEARCH ASSISTANCE AND TRAINING OPPORTUNITIES. ACTIVITIES TO BE PERFORMED: WIOA SPECIFIES THAT MOST ADULT PROGRAM SERVICES WILL BE PROVIDED THROUGH THE AMERICAN JOB CENTER NETWORK, ALSO KNOWN AS ONE-STOP CENTERS. UNDER THE WIOA ADULT PROGRAM, ELIGIBLE INDIVIDUALS CAN RECEIVE CAREER SERVICES, WHICH ARE CLASSIFIED INTO TWO CATEGORIES: BASIC AND INDIVIDUALIZED SERVICES. WHILE SOME JOB SEEKERS MAY ONLY NEED SELF-SERVICE OR OTHER BASIC CAREER SERVICES SUCH AS LABOR EXCHANGE SERVICES, OTHERS MAY NEED MORE COMPREHENSIVE SERVICES, SUCH AS INDIVIDUALIZED SERVICES, WHICH INCLUDE CAREER PLANNING, AND DEVELOPING AN INDIVIDUAL EMPLOYMENT PLAN OUTLINING NEEDS AND GOALS OF THE JOB SEEKER. PARTICIPANTS WILL ALSO RECEIVE TRAINING SERVICES LINKED TO JOB OPPORTUNITIES IN THEIR COMMUNITIES. TO PROMOTE CUSTOMER CHOICE AND INVOLVEMENT IN CAREER DECISIONS, PARTICIPANTS USE AN INDIVIDUAL TRAINING ACCOUNT TO SELECT AN APPROPRIATE TRAINING PROGRAM FROM AN ELIGIBLE TRAINING PROVIDER LIST. WIOA ALSO AUTHORIZES THE PROVISION OF SUPPORTIVE SERVICES (E.G. TRANSPORTATION AND CHILDCARE ASSISTANCE) TO ENABLE AN INDIVIDUAL TO PARTICIPATE IN THE PROGRAM.EXPECTED OUTCOMES: THE WIOA ADULT PROGRAM OUTCOMES ARE TO ENSURE THAT INDIVIDUALS CAN ACCESS AND RECEIVE THE EMPLOYMENT AND TRAINING SERVICES THEY ARE ELIGIBLE FOR, SO THAT THEY MAY BECOME EMPLOYED OR ADVANCE IN EMPLOYMENT. GRANTEES REPORT PERFORMANCE MEASURES OF THESE OUTCOMES, INCLUDING THE PERCENTAGE OF PEOPLE EMPLOYED IN THE SECOND AND FOURTH QUARTER AFTER FINISHING THE PROGRAM, THEIR EARNINGS, AND THE PERCENTAGE OF PEOPLE WHO OBTAINED A CREDENTIAL.INTENDED BENEFICIARIES: WIOA ADULT FUNDS MUST GIVE PRIORITY TO RECIPIENTS OF PUBLIC ASSISTANCE, OTHER LOW-INCOME INDIVIDUALS, AND INDIVIDUALS WHO ARE BASIC SKILLS DEFICIENT. OTHER CATEGORIES INCLUDE UNEMPLOYED ADULTS, DISLOCATED WORKERS, VETERANS, INDIVIDUALS WITH BARRIERS TO EMPLOYMENT, AND ANY ELIGIBLE POPULATION.SUBRECIPIENT ACTIVITIES: THE GRANTEES MAY SUBAWARD FUNDS FROM THE WIOA ADULT PROGRAM TO PROVIDE SOME OF THE INDIVIDUALIZED CAREER SERVICES, TRAINING, AS WELL AS PROVIDE SUPPORTIVE SERVICES. | labor |
| — | PUBLIC HEALTH, MASSACHUSETTS DEPARTMENT OF | Department of Agriculture | $32,883,935 | WIC ADMIN EXPENSES | social-services |
| — | PACIFIC INSTITUTE FOR RESEARCH & EVALUATION | Department of Health and Human Services | $32,873,693 | ENVIRONMENTAL APPROACHES TO PREVENTION | health |
| — | VISIONQUEST NATIONAL LTD | Department of Health and Human Services | $32,828,327 | RESIDENTIAL (SHELTER AND/OR TRANSITIONAL FOSTER CARE) SERVICES FOR UNACCOMPANIED CHILDREN-LICENSED AND TEXAS-EXEMPT AND FLORIDA-DELICENSED ONLY - THE VQ SAM MAHAN CENTER IS A SHELTER CARE PROGRAM FOR MALE UC AGES 12 TO 17 WITH A FUNDED CAPACITY OF 48, LOCATED IN BENSON, ARIZONA. THE PROGRAM OFFERS FULL ON SITE EDUCATION, CASE CASE MANAGEMENT AND CLINICAL SERVICES. FOR THE CALENDAR YEAR OF 2022: THE PROGRAM HAS A SUCCESSFUL DISCHARGE RATE OF 100% (ALL DISCHARGES EXCEPT RUNAWAYS) TOTAL YOUTH SERVED: 420; 4 AGE REDETERMINATIONS; 1 SUCCESSFULLY TRANSFERRED TO URM PROGRAM; 411 REUNIFICATIONS; 4 TRANSFERS TO OTHER ORR PROGRAMS | social-services |
| — | DISTRICT OF COLUMBIA, GOVERNMENT OF | Department of Health and Human Services | $32,808,390 | EMERGENCY PUBLIC HEALTH RESPONSE | health |
| — | NORTHCOAST CHILDREN'S SERVICES, INC | Department of Health and Human Services | $32,763,960 | HEAD START AND EARLY HEAD START | social-services |
| — | SOUTH CAROLINA DEPARTMENT OF TRANSPORTATION | Department of Transportation | $32,734,960 | PROJECT TITLE: I-26 CORRIDOR IMPROVEMENT FROM EXIT 125 TO EXIT 139 :::: PROJECT DESCRIPTION: I-26 CORRIDOR IMPROVEMENT FROM EXIT 125 OLD SANDY RUN ROAD TO EXIT 139 BURKE ROAD | transportation |
| — | ALBERT EINSTEIN COLLEGE OF MEDICINE | Department of Health and Human Services | $32,687,125 | CENTRAL AFRICA IEDEA | biotech |
| — | MAYO CLINIC JACKSONVILLE (A NONPROFIT CORPORATION) | Department of Health and Human Services | $32,683,845 | BIOLOGY AND PATHOBIOLOGY OF APOE IN AGING AND ALZHEIMER'S DISEASE - PROJECT SUMMARY (APOE U19: OVERALL) THE OVERARCHING GOAL OF THIS U19 PROJECT IS TO COMPREHENSIVELY UNDERSTAND THE BIOLOGY AND PATHOBIOLOGY OF APOLIPOPROTEIN E (APOE) IN AGING AND ALZHEIMER’S DISEASE (AD) TO INFORM THERAPEUTIC STRATEGIES. THE E4 ALLELE OF THE APOE GENE (APOE4) IS THE STRONGEST GENETIC RISK FACTOR FOR AD IMPACTING 50-70% OF ALL AD PATIENTS, WHILE THE E2 ALLELE IS PROTECTIVE COMPARED TO THE COMMON E3 ALLELE. APOE4 IS ALSO A STRONG RISK FACTOR FOR AGE-RELATED COGNITIVE DECLINE AND VASCULAR COGNITIVE IMPAIRMENT. TO INTEGRATE EXISTING KNOWLEDGE AND ADDRESS CRITICAL GAPS, WE PROPOSE A UNIFIED APOE CASCADE HYPOTHESIS THAT THE STRUCTURAL DIFFERENCES AND RELATED BIOCHEMICAL PROPERTIES AMONG THE THREE APOE ISOFORMS INITIATE THEIR DIFFERENTIAL EFFECTS ON A CASCADE OF EVENTS AT THE CELLULAR AND SYSTEMS LEVELS ULTIMATELY IMPACTING AGING-RELATED PATHOGENIC CONDITIONS INCLUDING AD. TOWARDS THIS, WE HAVE ASSEMBLED A MULTI-DISCIPLINARY TEAM TO SYNERGIZE EXPERTISE AND RESOURCES ACROSS MULTIPLE INSTITUTIONS. BY INTEGRATING FIVE INTERACTIVE PROJECTS AND SEVEN ROBUST CORES, WE WILL CREATE A NEXUS FOR APOE-RELATED AGING RESEARCH, SHARING THE KNOWLEDGE, EXPERTISE AND RESOURCES WITH THE BROADER SCIENTIFIC COMMUNITY. PROJECT 1 WILL WORK CLOSELY WITH CORE B TO ADDRESS THE STRUCTURAL AND BIOCHEMICAL PROPERTIES OF THE THREE APOE ISOFORMS TO GENERATE INSIGHTS FOR FUNCTIONAL OUTCOMES. PROJECTS 2, 3 AND 4 WILL INTERACTIVELY STUDY HOW APOE ISOFORMS EXPRESSED IN ASTROCYTES, MICROGLIA, OR VASCULAR MURAL CELLS IMPACT LIPID METABOLISM, GLIAL AND VASCULAR FUNCTIONS, AD-RELATED PATHOLOGIES, AND CELLULAR AND MOLECULAR PATHWAYS USING CONDITIONAL MOUSE MODELS AND SYSTEMS- BASED APPROACHES. THESE STUDIES WILL GENERATE CELL TYPE-SPECIFIC APOE/LIPOPROTEIN PARTICLES THAT WILL BE COLLECTED THROUGH IN VIVO MICRODIALYSIS FOR STRUCTURAL AND BIOCHEMICAL STUDIES. PROJECT 5 WILL CARRY OUT GENOMIC AND GENETIC ANALYSES TO IDENTIFY MODIFIERS OF APOE-RELATED AGE AT ONSET OF AD. STUDIES IN PROJECTS 2-5 WILL BE INTERACTIVELY SUPPLEMENTED BY NEUROPATHOLOGICAL STUDIES USING POSTMORTEM BRAINS FROM HEALTHY AGING STUDIES OR WITH AD PATHOLOGIES (CORE C), BIOMARKER STUDIES USING BOTH HUMAN AND MOUSE BIOSPECIMENS (CORE D), AND FUNCTIONAL STUDIES USING HUMAN IPSC-DERIVED CELLULAR AND ORGANOID MODELS (CORE E). THIS U19 PROPOSAL IS SUPPORTED BY A COMPREHENSIVE MULTI-OMICS CORE (CORE F) FOR CENTRALIZED PROTEOMICS, LIPIDOMICS, AND METABOLOMICS STUDIES ON VARIOUS ANIMAL AND IPSC MODELS, AS WELL AS HUMAN POSTMORTEM BRAINS AND FLUID BIOSPECIMENS. THE BIOINFORMATICS, BIOSTATISTICS, AND DATA MANAGEMENT CORE (CORE G) WILL PROVIDE CRITICAL SUPPORTS FOR ANALYZING LARGE DATASETS INCLUDING THOSE FROM SINGLE-CELL RNA-SEQ AND BIOSTATISTICS SUPPORTS TO ENSURE SCIENTIFIC RIGOR. CORE G WILL ALSO WORK CLOSELY WITH THE ADMINISTRATIVE CORE (CORE A) TO MAINTAIN AN APOE WEB PORTAL DESIGNATED AS EPAAD WHERE KNOWLEDGE, RESOURCES, AND DATA WILL BE SHARED WITH THE SCIENTIFIC COMMUNITY. CORE A WILL ALSO ORGANIZE ANNUAL APOE SYMPOSIUM TO PROMOTE COLLABORATION AND ENGAGE THE APOE COMMUNITY. AS SUCH, THIS U19 WILL DRIVE A TEAM-BASED EFFORT TO GENERATE ESSENTIAL KNOWLEDGE TO GUIDE DISEASE- MODIFYING THERAPIES FOR AD AND OTHER AGING-RELATED CONDITIONS. | biotech |
| — | COMMONWEALTH OF MASSACHUSETTS DEPT OF CHILDREN & FAMILIES | Department of Health and Human Services | $32,659,042 | SSBG-2024 | social-services |
| — | POARCH BAND OF CREEK INDIANS | Department of Housing and Urban Development | $32,587,218 | INDIAN HSG BLOCK GR | housing |
| — | DIVISION OF CHILD AND FAMILY SERVICES | Department of Health and Human Services | $32,559,618 | FOSTER-2026 - FOSTER CARE | social-services |
| — | COMMUNITY HEALTH CENTER OF SNOHOMISH COUNTY | Department of Health and Human Services | $32,513,043 | HEALTH CENTER CLUSTER | health |
| — | GREATER SEACOAST COMMUNITY HEALTH | Department of Health and Human Services | $32,487,228 | HEALTH CENTER CLUSTER | health |
| — | UNIVERSITY OF ARIZONA | National Science Foundation | $32,471,912 | NSF ENGINEERING RESEARCH CENTER FOR QUANTUM NETWORKS (CQN) | ai-infrastructure |
| — | SUMMIT EARLY LEARNING INC | Department of Health and Human Services | $32,386,098 | HEAD START AND EARLY HEAD START | social-services |
| — | THE HEALTH & HOSPITAL CORPORATION OF MARION COUNTY | Department of Health and Human Services | $32,380,679 | HEALTH CENTER CLUSTER | health |
| — | PEDIATRIC AND FAMILY MEDICAL FOUNDATION | Department of Health and Human Services | $32,370,273 | HEALTH CENTER CLUSTER | health |
| — | OREGON MILITARY DEPARTMENT | Department of Homeland Security | $32,356,378 | GRANT TO LOCAL GOVERNMENT FOR REPAIR OR REPLACEMENT OF DISASTER DAMAGED FACILITIES | environment |
| — | MINNESOTA DEPARTMENT OF HEALTH | Department of Health and Human Services | $32,345,172 | COOPERATIVE AGREEMENT FOR EMERGENCY RESPONSE: PUBLIC HEALTH CRISIS RESPONSE - 2018 | health |
| — | DEPARTMENT OF CHILD SERVICES | Department of Health and Human Services | $32,328,551 | SSBG-2024 | social-services |
| — | CINCINNATI UNIV OF | Department of Health and Human Services | $32,294,153 | NSTN NATIONAL CLINICAL COORDINATING CENTER | biotech |
| — | EXECUTIVE OFFICE OF THE STATE OF NEW HAMPSHIRE | Department of Health and Human Services | $32,230,943 | LIHEAP-2026 - LOW INCOME HOME ENERGY ASSISTANCE | social-services |
| — | OKLAHOMA DEPARTMENT OF MENTAL HEALTH AND SUBSTANCE ABUSE SERVICES | Department of Health and Human Services | $32,214,595 | ODMHSAS SOSIII - THE OKLAHOMA DEPARTMENT OF MENTAL HEALTH AND SUBSTANCE ABUSE SERVICES ODMHSAS IS REQUESTING 15,795,312 FOR A THREE YEAR STATE OPIOID AND STIMULANT SOS3 INITIATIVE, TO ADDRESS THE CRITICAL PUBLIC HEALTH CRISIS POSED BY OPIOID AND OTHER STIMULANT MISUSE. THE FOCUS IS ON THREE PRIORITY AREAS: PREVENTION, TREATMENT, AND RECOVERY SUPPORT SERVICES. THE STATEWIDE INITIATIVE TARGETS THE UNINSURED, UNDERINSURED, AND DIVERSE UNDERSERVED INDIVIDUALS AND THEIR FAMILIES, INCLUDING NATIVE AMERICANS, TRIBAL COMMUNITIES, PERSONS DISCHARGED FROM INCARCERATION, VETERANS, PREGNANT AND POST PARTEM WOMEN, AND TRANSITIONING YOUTH. WHILE METHAMPHETAMINE REMAINS THE GREATEST DRUG THREAT IN OKLAHOMA, WITH THE OKLAHOMA BUREAU OF NARCOTICS AND DANGEROUS DRUGS OBNDD REPORTING 729 METHAMPHETAMINE-RELATED FATAL OVERDOSES IN 2022, A 22% INCREASE FROM THE PREVIOUS YEAR, SYNTHETIC OPIOIDS AND FENTANYL-LACED COUNTERFEIT PRESCRIPTION PILLS HAVE SURGED, CONTRIBUTING TO 1,721 FATAL OVERDOSES IN 2022. THE NUMBER OF OVERDOSE DEATHS INVOLVING FENTANYL IN 2022 WAS NEARLY 16 TIMES HIGHER THAN IN 2018. THE OKLAHOMA SOS3 PROJECT WILL IMPLEMENT A COMPREHENSIVE CONTINUUM OF PREVENTION, HARM REDUCTION, TREATMENT, AND RECOVERY SUPPORT SERVICES, ADDRESSING CONCURRENT SUBSTANCE ABUSE DISORDERS. THE INITIATIVE AIMS TO INCREASE COMMUNITY KNOWLEDGE TO PREVENT OPIOID AND STIMULANT ABUSE WHILE ENHANCING ACCESS TO SERVICES. IT WILL EXPAND COMMUNITY OUTREACH THROUGH TRAINING AND LOCAL ACTION ON OPIOID AND STIMULANT MISUSE PREVENTION. ADDITIONALLY, THE PROGRAM SEEKS TO ENHANCE WORKFORCE KNOWLEDGE AND SUPPORT FOR INDIVIDUALS AT RISK OR WITH OPIOID USE DISORDER (OUD), THEIR FAMILIES, AND THE COMMUNITY THROUGH TRAINING, CONSULTATION, AND NALOXONE DISTRIBUTION. PROMOTING SOCIAL AND EMOTIONAL HEALTH FOR STUDENTS TO REDUCE DISRUPTIVE BEHAVIOR AND IMPROVE INSTRUCTIONAL TIME IS ANOTHER KEY FOCUS. THE INITIATIVE WILL ALSO STRENGTHEN COMMUNITY REFERRAL NETWORKS FOR INDIVIDUALS WITH OUD BY MOBILIZING REGIONAL RESOURCES AND INCREASING ACCESS TO A RANGE OF TREATMENTS FOR OUD AND SUBSTANCE USE DISORDERS SUDS, INCLUDING FDA-APPROVED MEDICATIONS FOR OUD AND STIMULANT MISUSE. TO ACHIEVE THESE GOALS, THE SOS PROGRAM WILL COLLABORATE CLOSELY WITH TREATMENT PROVIDERS AND INSTITUTIONS SERVING VULNERABLE POPULATIONS. THIS PARTNERSHIP AIMS TO EDUCATE AND EMPOWER AT RISK INDIVIDUALS AND THEIR COMMUNITIES BY PROVIDING OVERDOSE PREVENTION EDUCATION, FACILITATING TREATMENT REFERRALS, AND CONNECTING INDIVIDUALS WITH LOCAL SUPPORT NETWORKS. BY ALIGNING STATE AND GRANT FUNDING, ODMHSAS WILL MAXIMIZE RESOURCES, AVOID DUPLICATION OF EFFORTS, AND EXTEND SERVICES TO MORE INDIVIDUALS AND FAMILIES IN NEED. | health |
| — | UNIVERSITY OF ILLINOIS | Department of Health and Human Services | $32,192,695 | HEALTH CENTER CLUSTER | health |
| — | DEPARTMENT OF EARLY CARE & LEARNING GEORGIA | Department of Agriculture | $32,146,748 | SCHOOL FOOD PROGRAMS | agriculture |
| — | GUAM WATERWORKS AUTHORITY | Environmental Protection Agency | $32,136,633 | DESCRIPTION:THIS AGREEMENT INCLUDES FISCAL YEAR 2025 INFRASTRUCTURE INVESTMENT AND JOBS ACT (IIJA) AWARDS, WHICH INCLUDES DRINKING WATER STATE REVOLVING FUND GENERAL SUPPLEMENTAL, CLEAN WATER STATE REVOLVING FUND GENERAL SUPPLEMENTAL, CLEAN WATER EMERGING CONTAMINANT FUNDS, DRINKING WATER EMERGING CONTAMINANT FUNDS, AND LEAD SERVICE LINE REPLACEMENT FUNDS. THE PROJECT WORKPLAN IS TARGETED TO MEET THE STATUTORY AND REGULATORY OBJECTIVES, MILESTONES, AND GOALS OF EPA'S STRATEGIC PLAN, IN CONJUNCTION WITH THE AUTHORITY AND LEGISLATIVE INTENT OF THE OMNIBUS TERRITORIES ACT. PLANNED PROJECTS ARE DERIVED FROM THE GUAM WATERWORKS AUTHORITY (GWA) PROJECT PRIORITY LIST. THE SPECIFIC PROJECT PRIORITIES MAY CHANGE THROUGHOUT THE PERIOD OF PERFORMANCE, WHICH ARE DEPENDENT ON THE NEEDS BASIS OF PROTECTING HUMAN HEALTH AND THE ENVIRONMENT. THIS YEAR'S AWARD WILL FUND CONSTRUCTION FOR FATS, OILS, AND GREASE (FOG) RECEIVING FACILITY AT NORTHERN DISTRICT WASTEWATER TREATMENT PLANT (NDWWTP), HAGATNA FORCEMAIN, GENERAL WATERLINE REPLACEMENT, BOOSTER PUMPS AND DIELDRIN MITIGATION. THIS AGREEMENT PROVIDES FULL FEDERAL FUNDING IN THE AMOUNT OF $32,136,633. REFER TO TERMS AND CONDITIONS. ACTIVITIES:THIS AGREEMENT INCLUDES INFRASTRUCTURE INVESTMENT AND JOBS ACT FUNDS FOR FISCAL YEAR 2025. THE FULL DETAILED WORKPLAN IS ATTACHED AND DESCRIBES THE OBJECTIVES, MILESTONES, AND GOALS THAT MEET THE REQUIREMENTS OF EPA'S STRATEGIC PLAN, GOVERNMENT PERFORMANCE AND RESULTS ACT (GPRA), STATUTES, REGULATIONS, AND IS BEING DONE WITH THE AUTHORITY AND LEGISLATIVE INTENT OF THE OMNIBUS TERRITORIES ACT. THE PROPOSED PROJECTS ARE TAKEN FROM THE USEPA APPROVED GUAM EPA PROJECT PRIORITY LIST, HOWEVER, THE SPECIFIC PROJECT PRIORITIES MAY CHANGE THROUGH THE YEARS DEPENDENT ON THE NEED OF ADDRESSING PROTECTION OF HUMAN HEALTH AND THE ENVIRONMENT. THE PROPOSED PROJECTS WILL FOCUS ON FOG RECEIVING FACILITY AT NDWWTP, HAGATNA FORCEMAIN, GENERAL WATERLINE REPLACEMENT, BOOSTER PUMPS AND DIELDRIN MITIGATION. THE PROPOSED ACTIVITIES AND BUDGET ARE DETAILED IN THE WORKPLAN, WHICH HAS BEEN NEGOTIATED AND APPROVED BY THE PROJECT OFFICER.SUBRECIPIENT:NO SUBAWARDS ARE INCLUDED IN THIS ASSISTANCE AGREEMENT.OUTCOMES:THE WATER AND WASTEWATER SYSTEM IMPROVEMENT PROJECTS' PRIMARY OBJECTIVES INCLUDE REPLACING OLD LEAKING WATER MAINS, UPGRADING UNDERSIZED MAINS REDUCING WATER LOSS AND THUS REDUCING PUBLIC HEALTH RISKS, REDUCING OPERATIONS AND MAINTENANCE COSTS, IMPROVING USEFUL LIFE OF ASSETS, AND MANAGING WATER SOURCES FOR FUTURE GENERATIONS. THESE PROJECTS ALSO AIM TO REDUCE CONTAMINATION IN SELECTED WELLS AND IMPROVE CONVEYANCE OF WASTEWATER, PREVENTING SANITARY SEWER OVERFLOWS (SSOS) AND PROTECTING PUBLIC HEALTH. | environment |
| — | THE NEMOURS FOUNDATION | Department of Health and Human Services | $32,008,364 | CHILDREN'S HOSPITALS GRADUATE MEDICAL EDUCATION PAYMENT PROGRAM | health |
| — | SECRETARY OF STATE OHIO | Election Assistance Commission | $32,005,246 | "TO IMPROVE THE ADMINISTRATION OF ELECTIONS FOR FEDERAL OFFICE, INCLUDING TO ENHANCE ELECTION TECHNOLOGY AND MAKE ELECTION SECURITY IMPROVEMENTS" TO THE SYSTEMS, EQUIPMENT AND PROCESSES USED IN FEDERAL ELECTIONS | justice |
| — | BROWARD COMMUNITY AND FAMILY HEALTH CENTERS, INC. | Department of Health and Human Services | $31,979,870 | HEALTH CENTER CLUSTER | health |
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