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Federal awards
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Agency: Department of Health and Human Services
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1,662 awards
Showing 1601–1650
| Action date | Recipient | Agency | Amount | Description | Sector |
|---|---|---|---|---|---|
| — | BOSTON HEALTH CARE FOR THE HOMELESS PROGRAM | Department of Health and Human Services | $34,625,564 | HEALTH CENTER CLUSTER | health |
| — | COMPASS CONNECTIONS | Department of Health and Human Services | $34,622,895 | RESIDENTIAL (GROUP HOME, SHELTER, TRANSITIONAL FOSTER CARE) SERVICES FOR UNACCOMPANIED ALIEN CHILDREN - COMPASS CONNECTIONS IS A FEDERALLY FUNDED RESIDENTIAL SHELTER PROGRAM WITHIN THE OFFICE OF REFUGEE RESETTLEMENT (ORR) THAT PROVIDES TEMPORARY CARE AND SERVICES FOR UNACCOMPANIED ALIEN CHILDREN ARRIVING IN THE UNITED STATES WITHOUT PARENTS OR LEGAL GUARDIANS. THE PROGRAM ENSURES CHILDREN RECEIVE ESSENTIAL SERVICES INCLUDING HOUSING, MEDICAL CARE, EDUCATION, AND MENTAL HEALTH SUPPORT WHILE IDENTIFYING AND VETTING SUITABLE SPONSORS THROUGH COMPREHENSIVE BACKGROUND CHECKS. THE PRIMARY OBJECTIVE IS TO SAFELY REUNITE CHILDREN WITH VETTED SPONSORS IN THE LEAST RESTRICTIVE ENVIRONMENT WHILE MAINTAINING ONGOING CASE MANAGEMENT AND SUPPORT SERVICES. | social-services |
| — | MAINLINE HEALTH SYSTEMS INC | Department of Health and Human Services | $34,539,430 | HEALTH CENTER CLUSTER | health |
| — | PORTSMOUTH COMMUNITY HEALTH CENTER, INC. | Department of Health and Human Services | $34,450,302 | HEALTH CENTER CLUSTER | health |
| 2026-02-26 | GUIDEHOUSE INC. | Department of Health and Human Services | $34,425,914 | IBAPS IT TECHNICAL AND FUNCTIONAL SERVICES; HFP MODULES DME, PM AS WELL AS O&M SUPPORT | health |
| — | ST. FRANCIS HOUSE NWA, INC. | Department of Health and Human Services | $34,407,047 | HEALTH CENTER CLUSTER | health |
| — | UNIVERSITY OF MASSACHUSETTS | Department of Health and Human Services | $34,373,409 | NATIONAL CENTER ON PROGRAM MANAGEMENT AND FISCAL OPERATIONS | social-services |
| — | UNIVERSITY OF SOUTHERN CALIFORNIA | Department of Health and Human Services | $34,372,705 | A NEXT GENERATION DATA INFRASTRUCTURE TO UNDERSTAND DISPARITIES ACROSS THE LIFE COURSE - SUMMARY THIS INFRASTRUCTURE PROPOSAL AIMS TO FURTHER ADVANCE CAPABILITIES IN THE SOCIAL SCIENCES (BROADLY DEFINED) TO COLLECT DATA ON THE DAILY LIVES OF U.S. FAMILIES AND INDIVIDUALS. THESE DATA WILL BE MORE ACCURATE, MORE GRANULAR, AND MORE COMPREHENSIVE THAN IS CURRENTLY POSSIBLE IN TRADITIONAL SURVEY-BASED RESEARCH. THE CONTEXT FOR THIS IS THE UNDERSTANDING AMERICA STUDY (UAS), THE PROBABILITY-BASED INTERNET PANEL WE HAVE BEEN BUILDING AT USC SINCE 2014. THE INFRASTRUCTURE INCLUDES THE COMBINATION OF MANY DATA TYPES (INCLUDING SURVEY DATA, INFORMATION FROM WEARABLES, CONTEXTUAL AND ADMINISTRATIVE LINKAGES, ECOLOGICAL MOMENTARY ASSESSMENTS, SELF-RECORDED NARRATIVES, AND ELECTRONIC RECORDS OF FINANCIAL TRANSACTIONS), AS WELL AS AN OPEN COMMUNICATION WITH THE WIDER RESEARCH COMMUNITY BOTH IN DATA DISSEMINATION AND IN SOLICITING INPUT ON CONTENT AND METHODS. THE UAS CURRENTLY COMPRISES ABOUT 10,000 U.S. RESIDENTS (INCLUDING A 2,500 PERSON CALIFORNIA OVERSAMPLE), RECRUITED BY ADDRESS-BASED SAMPLING AND PROVIDED WITH INTERNET-ENABLED TABLETS IF NEEDED. SURVEYS ARE CONDUCTED IN ENGLISH AND SPANISH. WE PROPOSE TO EXPAND THE UAS NATIONAL SAMPLE TO 20,000 RESPONDENTS, WITH SUBSAMPLES OF BLACKS, ASIANS, AND HISPANICS OF AT LEAST 3,000 EACH. THE INFORMATION COLLECTED WILL FOCUS ON FACTORS EXPLAINING RACIAL AND SOCIO-ECONOMIC DISPARITIES OVER THE LIFE COURSE, INCLUDING RACIAL DISCRIMINATION, INEQUALITIES IN ACCESS TO EDUCATION AND HEALTHCARE, DIFFERENCES IN THE PHYSICAL AND SOCIAL ENVIRONMENT, AND, MORE GENERALLY, THE VARIOUS OPPORTUNITIES AND OBSTACLES ONE ENCOUNTERS OVER THE LIFE COURSE. THE PROPOSED PROJECT TEAM COVERS A BROAD SPECTRUM OF SUBSTANTIVE EXPERTISE ON DISPARITIES, RACIAL DISCRIMINATION, ENVIRONMENTAL HEALTH, CHILD DEVELOPMENT, HEALTH, AND COGNITION OVER THE LIFE COURSE, AS WELL AS AGING AND RETIREMENT, CONSUMPTION, WORK, AND INCOME. TO ENCOURAGE INPUT FROM THE RESEARCH COMMUNITY, WE ENVISION A PROGRAM OF ADDED SURVEY MODULES ON INEQUALITY-RELATED TOPICS PROPOSED BY OUTSIDE RESEARCHERS, AS WELL AS AN ANNUAL RESEARCH CONFERENCE. THE BASIC PREMISE UNDERLYING THE PROJECT IS THAT THE ONLY FEASIBLE APPROACH TO COMPREHENSIVELY INVESTIGATING THE IMPACT OF DIFFERENCES IN THE LIFE COURSE ON OBSERVED INEQUALITY IS TO ENACT A ROBUST MULTI-METHOD APPROACH THAT PROVIDES THE MEANS OF ACCOUNTING FOR AS MANY EXPLANATORY FACTORS AS POSSIBLE. WITHIN THAT CONTEXT, NATURALLY OCCURRING EXPERIMENTS CAN BE EXPLOITED TO HELP IDENTIFY CAUSAL PATHWAYS OF INTEREST (E.G., WHEN AIR QUALITY IN A NEIGHBORHOOD IMPROVES DUE TO A PLANT CLOSURE; A POLICY CHANGE THAT AFFECTS THE QUALITY OF SCHOOLS IN A CERTAIN AREA). THUS, OUR PROPOSED PROJECT AIMS TO CREATE AND MAKE AVAILABLE TO THE RESEARCH COMMUNITY A UNIQUELY DETAILED AND FOCUSED COLLECTION OF INFORMATION ON U.S. HOUSEHOLDS AND INDIVIDUALS. TO ACHIEVE THIS GOAL, WE AIM TO STRATEGICALLY INTEGRATE SELECTED EXTERNAL DATA SOURCES WITH UAS SURVEY DATA AND EXPAND THE ALREADY BROAD SET OF TOPICS COVERED BY UAS SURVEYS. | health |
| — | WEST VIRGINIA DEPT OF HUMAN SERVICES | Department of Health and Human Services | $34,368,027 | LIHEAP-2026 - LOW INCOME HOME ENERGY ASSISTANCE | social-services |
| — | RURAL HEALTH SERVICES CONSORTIUM, INC | Department of Health and Human Services | $34,211,519 | HEALTH CENTER CLUSTER | health |
| 2026-03-17 | PARAGON SYSTEMS INC | Department of Health and Human Services | $34,203,622 | STRATEGIC NATIONAL STOCKPILE PROTECTIVE GUARD SERVICES | health |
| — | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE | Department of Health and Human Services | $34,183,375 | KENTUCKY CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE | health |
| 2026-04-20 | ICON GOVERNMENT AND PUBLIC HEALTH SOLUTIONS, INC. | Department of Health and Human Services | $34,081,098 | CLINICAL TRIAL PLANNING AND EXECUTION (CTPE) | biotech |
| — | THE JOHNS HOPKINS UNIVERSITY | Department of Health and Human Services | $34,078,316 | JOHNS HOPKINS AIDS CLINICAL TRIALS UNIT | health |
| — | COMMUNITY HEALTH OF CENTRAL WASHINGTON | Department of Health and Human Services | $34,016,097 | HEALTH CENTER CLUSTER | health |
| — | PRIMARY HEALTH SERVICES CENTER | Department of Health and Human Services | $33,988,808 | HEALTH CENTER CLUSTER | health |
| — | TELAMON CORPORATION | Department of Health and Human Services | $33,944,753 | MIGRANT AND SEASONAL HEAD START AND EARLY HEAD START | social-services |
| — | TENNESSEE DEPARTMENT OF HUMAN SERVICES | Department of Health and Human Services | $33,920,929 | SSBG-2024 | social-services |
| — | INDIANA FAMILY AND SOCIAL SERV | Department of Health and Human Services | $33,894,092 | GY2024 ORR REFUGEE CASH AND MEDICAL ASSISTANCE | social-services |
| — | UNIVERSITY OF CALIFORNIA, SAN DIEGO | Department of Health and Human Services | $33,848,843 | UNIVERSITY OF CALIFORNIA, SAN DIEGO CLINICAL TRIAL UNIT | health |
| — | ARIZONA DEPARTMENT OF ECONOMIC SECURITY | Department of Health and Human Services | $33,809,170 | LIHEAP-2026 - LOW INCOME HOME ENERGY ASSISTANCE | social-services |
| — | NATIONAL OPINION RESEARCH CENTER | Department of Health and Human Services | $33,729,002 | HEALTHCARE COST AND UTILIZATION PROJECT (HCUP) CLIN 0002 BASE AWARD | health |
| — | NATIONAL JEWISH HEALTH | Department of Health and Human Services | $33,715,767 | AIRWAY TRANSCRIPTOMIC RESPONSES TO COVID-19 ILLNESSES IN THE HUMAN EPIDEMIOLOGY AND RESPONSE TO SARS-COV-2 (HEROS) COHORT | biotech |
| — | ANTHONY L. JORDAN HEALTH CORPORATION | Department of Health and Human Services | $33,708,447 | HEALTH CENTER CLUSTER | health |
| — | CAHABA MEDICAL CARE FOUNDATION | Department of Health and Human Services | $33,707,582 | HEALTH CENTER CLUSTER | health |
| — | YAKIMA NEIGHBORHOOD HEALTH SERVICES | Department of Health and Human Services | $33,664,201 | HEALTH CENTER CLUSTER | health |
| — | BEAUFORT JASPER ECONOMIC OPPORTUNITY COMMISSION, INC. | Department of Health and Human Services | $33,606,226 | HEAD START AND EARLY HEAD START | social-services |
| — | NORTHSHORE HEALTH CENTERS, INC | Department of Health and Human Services | $33,567,517 | HEALTH CENTER CLUSTER | health |
| — | TACOMA PUBLIC SCHOOLS | Department of Health and Human Services | $33,528,411 | HEAD START | social-services |
| — | ORANGE COUNTY HEALTH CARE AGENCY | Department of Health and Human Services | $33,444,310 | COMPONENT A-STRENGTHENING A1 WORKFORCE AND A2 FOUNDATIONAL CAPABILITIES - ORANGE COUNTY HEALTH CARE AGENCY (HCA) IS COMMITTED TO ONGOING TRANSFORMATION OF THE PUBLIC HEALTH SYSTEM TO MEET THE EVER-CHANGING AND MULTIFACETED NEEDS OF OUR TARGET POPULATIONS. HCA IS WELL-ACQUAINTED WITH OUR RESIDENTS’ NEEDS AND CHALLENGES, PROVIDING UNIQUE INSIGHTS TO BUILD A FRAMEWORK THAT CAN ENABLE EMPOWERMENT, REVITALIZATION, HEALTH EQUITY, AND OPPORTUNITIES TO MOVE THE NEEDLE ON VARIOUS SOCIAL DETERMINANTS OF HEALTH WITHIN ORANGE COUNTY. THIS FUNDING WILL ALLOW HCA TO FURTHER MOBILIZE COMMUNITY ASSETS AND ENGAGE THOSE WHO HAVE BEEN ECONOMICALLY OR SOCIALLY MARGINALIZED, MEDICALLY UNDERSERVED, RACIAL, AND ETHNIC MINORITY GROUPS, AND THOSE DISPROPORTIONATELY AFFECTED BY PUBLIC HEALTH ISSUES. HCA’S SCOPE OF RESPONSIBILITY INCLUDES MENTAL HEALTH & RECOVERY, PUBLIC HEALTH, ENVIRONMENTAL HEALTH, CORRECTIONAL HEALTH, COUNTY EMPLOYEE HEALTH, EMERGENCY MANAGEMENT. ORANGE COUNTY’S POPULATION AND DEMOGRAPHIC CONTINUE TO GROW AND BECOME MORE DIVERSE. HCA’S ABILITY TO MEET THE NEEDS OF OUR RESIDENTS WILL CONTINUE TO INCLUDE COLLABORATIONS WITH THE PUBLIC-PRIVATE MULTISECTOR IN THE COMMUNITY FOCUSING ON THE CREATION OF A COORDINATED AND EQUITABLE CONTINUUM OF HUMAN AND HEALTH SERVICES. AS SUCH, HCA’S PROJECT PLAN FOCUSES ON CREATING A DATA-DRIVEN, HEALTH EQUITY FOCUSED WORKFORCE BY TRAINING A HEALTHY POOL OF TALENT WITH EDUCATIONAL AND TRAINING PROGRAMS ALIGNED WITH THE CURRENT COMMUNITY NEEDS. A PRIMARY ACTIVITY WILL BE TO MAKE AN UPSTREAM INVESTMENT IN EDUCATION TO ADDRESS WORKFORCE DEFICIENCIES ACROSS THE PUBLIC HEALTH SYSTEM. HCA WILL CREATE A LEARNING COLLABORATIVE AIMED AT IMPROVING THE QUALITY, QUANTITY, DISTRIBUTION, AND DIVERSITY OF THE PUBLIC HEALTH WORKFORCE. WORKFORCE CAPACITY BUILDING WILL FOCUS ON ADDRESSING COMPLEX HEALTH NEEDS IN OUR VULNERABLE COMMUNITIES SUCH AS THE RACIAL/ETHNIC, TRANSITIONAL AGE YOUTH, ELDERLY, AND LGBTQ+ COMMUNITIES. THE PLAN WILL ALSO ENSURE THAT THE WEALTH OF ORGANIZATIONAL PUBLIC HEALTH KNOWLEDGE IS SUSTAINED AFTER THE FUNDING PERIOD ENDS AND THAT THE DEVELOPMENT OF EXPERTISE IS ALIGNED TO SUPPORT THE IMPLEMENTATION OF THE CORE PUBLIC HEALTH FUNCTIONS FOR MANY MORE GENERATIONS TO COME. HCA’S INVESTMENTS IN KEY TECHNOLOGIES, CAPABILITIES, AND TECHNICAL ASSISTANCE THROUGH THIS FUNDING WILL INCREASE OUR EFFECTIVENESS IN BUILDING THE SKILLS AND TALENT NECESSARY TO DELIVER PUBLIC HEALTH SERVICES ON A SCALE APPROPRIATE FOR THE SIXTH LARGEST COUNTY IN THE NATION. HCA WILL USE THIS FUNDING TO STRENGTHEN OUR OVERALL SYSTEMS, PROCESSES, AND POLICIES TO ENSURE A STRONG CORE INFRASTRUCTURE TO ACHIEVE A COLLECTIVE VISION OF COMMUNITY HEALTH FOR ALL. EFFORTS AROUND BUILDING A ROBUST DATA INFRASTRUCTURE WILL FURTHER STRENGTHEN HCA’S COMMITMENT IN USING DATA TO INFORM PROGRAMMATIC AND POLICY DECISIONS, AS WELL AS ELIMINATING HEALTH DISPARITIES AND ACHIEVING HEALTH EQUITY IN ORANGE COUNTY. HCA’S COMMUNICATIONS ENHANCEMENT INITIATIVE WILL SUPPORT INNOVATIVE MESSAGING STRATEGIES TO EQUIP OUR COMMUNITY LEADERS WITH RELIABLE DATA AND FEEDBACK FROM TARGET POPULATIONS TO INFORM STRATEGIC CHANGE, SHAPE LEGISLATION AND POLICIES, AND MAKE DATA-DRIVEN DECISIONS ABOUT PUBLIC HEALTH PREVENTION. AN OVERARCHING PRINCIPLE OF THE PROJECT WILL BE TO STRENGTHEN EXISTING AND BUILD NEW PARTNERSHIPS WITH COMMUNITY ORGANIZATIONS, BUSINESSES, AND ACADEMIC INSTITUTIONS TO ALIGN AND MAXIMIZE OUTREACH STRATEGIES. HCA IS COMMITTED TO TRANSFORMING THE WAY COMMUNITY STAKEHOLDERS WORK TOGETHER IN ORANGE COUNTY TO DEVELOP SHARED SOLUTIONS AND ULTIMATELY BUILD AND SUSTAIN A ROBUST CORE PUBLIC HEALTH INFRASTRUCTURE. AFTER THE COMPLETION OF THIS FIVE-YEAR PLAN, IT IS OUR HOPE THAT ENDURING, INSTITUTIONALIZED CHANGES WILL BE ACHIEVED AT HCA TO CREATE A ROBUST, WELL-EQUIPPED PUBLIC HEALTH WORKFORCE CAPABLE IN MAKING SUBSTANTIAL CHANGES ACROSS THE COMPLEX SET OF PUBLIC HEALTH, MENTAL HEALTH, HEALTH EQUITY, AND SOCIAL DETERMINANTS OF HEALTH ISSUES. | health |
| — | COMMUNITY HEALTH SYSTEMS, INC. | Department of Health and Human Services | $33,409,267 | HEALTH CENTER CLUSTER | health |
| — | CENTER FOR CHILDREN AND FAMILY FUTURES, INC. | Department of Health and Human Services | $33,389,480 | THE PURPOSE OF THIS CONTRACT IS TO CONTINUE TO ADDRESS THESE PRIORITIES AS WELL AS THE PRIORITIES OF THE CURRENT NCSACW MISSION: TO IMPROVE SYSTEMS AND PRACTICES FOR FAMILIES WITH SUBSTANCE USE DISORDERS, CO-OCCURRING MENTAL HEALTH DISORDERS AND CHIL | health |
| — | SOUTH TEXAS RURAL HEALTH SERVICES INC | Department of Health and Human Services | $33,374,373 | HEALTH CENTER CLUSTER | health |
| — | TALLADEGA-CLAY-RANDOLPH CHILD CARE CORP | Department of Health and Human Services | $33,355,060 | HEAD START AND EARLY HEAD START | social-services |
| — | COMMUNITY ACTION PIONEER VALLEY, INC. | Department of Health and Human Services | $33,237,115 | HEAD START AND EARLY HEAD START | social-services |
| — | TEXAS BIOMEDICAL RESEARCH INSTITUTE | Department of Health and Human Services | $33,218,050 | ESTABLISHMENT OF A SPF RHESUS MACAQUE COLONY | biotech |
| — | MISSISSIPPI STATE UNIVERSITY | Department of Health and Human Services | $33,151,370 | HEAD START AND EARLY HEAD START | social-services |
| — | HEALTHY CONNECTIONS, INC. | Department of Health and Human Services | $33,123,395 | HEALTH CENTER CLUSTER | health |
| — | HEALTH & HUMAN SVC COMMN TX | Department of Health and Human Services | $33,037,776 | HHSC IS APPLYING FOR THE 988 STATE AND TERRITORY IMPROVEMENT OPPORTUNITY IN ORDER TO IMPROVE TEXAS' RESPONSE TO 988 CONTACTS (INCLUDING CALLS, CHATS, AND TEXTS) ORIGINATING IN TEXAS. - THE TEXAS HEALTH AND HUMAN SERVICES COMMISSION IS APPLYING FOR THE 988 STATE AND TERRITORY IMPROVEMENT PROJECT IN ORDER TO IMPROVE TEXAS' EXISTING 988 CRISIS RESPONSE SYSTEM. HHSC PLANS TO SERVE ALL TEXANS EXPERIENCING MENTAL HEALTH CRISES BY CONNECTING THEM TO A TRAINED CRISIS COUNSELOR WHO CAN ADDRESS THEIR IMMEDIATE NEEDS OR CONNECT THEM TO THE APPROPRIATE RESOURCES. IF AWARDED, HHSC PLANS TO IMPLEMENT A MULTI-FACETED APPROACH TO IMPROVE THE ALREADY EXISTING 988 SERVICES. THIS INCLUDES INCREASING THE IN-STATE ANSWER RATE, IMPROVING THE 988 INFRASTRUCTURE AND THE COORDINATION OF CRISIS RESPONSE SERVICES, IMPROVING 988 SUPPORT FOR HIGH-RISK POPULATIONS, ENSURING COMPREHENSIVE QUALITY ASSURANCE, AND INCREASING AWARENESS OF 988 AND AVAILABLE RESOURCES THROUGHOUT THE STATE. IN ORDER TO ACHIEVE THESE GOALS, HHSC WILL LEVERAGE ITS EXISTING ROBUST CRISIS CONTINUUM AND CONDUCT A COMPREHENSIVE REVIEW OF CURRENT STATEWIDE CAPABILITIES TO INFORM FUTURE DIRECTION DURING THE PROJECT PERIOD WHICH MAY INCLUDE CONTRACTING OR SUBCONTRACTING WITH ENTITIES TO EXPAND IN-STATE 988 SERVICE CAPACITY. HHSC PLANS TO CONTINUE BUILDING ON THE WORK ACCOMPLISHED THROUGH THE 988 STATE AND TERRITORY COOPERATIVE AGREEMENT AWARDED TO HHSC FOR APRIL 2022 THROUGH APRIL 2024. IN JANUARY 2022, TEXAS' IN-STATE ANSWER RATE WAS 45 PERCENT, AND BY APRIL 2023, THE IN-STATE ANSWER RATE INCREASED TO 75 PERCENT. ADDITIONALLY, THROUGH THE WORK OF THE 988 STATE AND TERRITORY COOPERATIVE AGREEMENT, HHSC PURSUED SUBSTANTIAL IMPROVEMENTS IN THE STATEWIDE 988 CRISIS SYSTEM BY EXPANDING PRIMARY AND BACKUP COVERAGE. HHSC WILL CONTINUE TO ALLOCATE FUNDING TO THE FOUR 988 CENTERS PROVIDING PRIMARY COVERAGE AND ONE 988 CENTER PROVIDING BACKUP COVERAGE IN ORDER TO EXPAND WORKFORCE AND REINFORCE SERVICES. HHSC HAS ALREADY BEGUN CREATING A COMMUNICATION STRATEGY PLAN TO ENSURE EDUCATION REGARDING 988 IS ACCESSIBLE TO ALL TEXANS, ESPECIALLY THOSE IN HIGH-RISK POPULATIONS. HHSC IS COMMITTED TO ENHANCING ITS QUALITY ASSURANCE PLAN TO ENSURE THOSE SERVED THROUGH 988 ARE RECEIVING THE BEST SERVICE POSSIBLE. HHSC AND ITS PARTNERS ARE STRONGLY COMMITTED TO WORKING TOWARDS THE MINIMUM REQUIRED IN-STATE ANSWER RATE OF 90 PERCENT BY THE END OF FISCAL YEAR 2026. HHSC WILL CONTRACT WITH PARTNERS TO ENSURE EFFORTS ARE INCREASED IN RECRUITING, HIRING, TRAINING, AND EXPANDING THE BEHAVIORAL HEALTH WORKFORCE IN TEXAS TO UNIFORMLY RESPOND LOCALLY TO PERSONS WHO CALL, CHAT, OR TEXT 988 SERVICES. | health |
| — | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE | Department of Health and Human Services | $33,001,188 | PENN PREVENTION CLINICAL TRIALS UNIT | biotech |
| — | JUNIPER HEALTH, INC. | Department of Health and Human Services | $32,969,946 | HEALTH CENTER CLUSTER | health |
| — | PACIFIC INSTITUTE FOR RESEARCH & EVALUATION | Department of Health and Human Services | $32,873,693 | ENVIRONMENTAL APPROACHES TO PREVENTION | health |
| — | VISIONQUEST NATIONAL LTD | Department of Health and Human Services | $32,828,327 | RESIDENTIAL (SHELTER AND/OR TRANSITIONAL FOSTER CARE) SERVICES FOR UNACCOMPANIED CHILDREN-LICENSED AND TEXAS-EXEMPT AND FLORIDA-DELICENSED ONLY - THE VQ SAM MAHAN CENTER IS A SHELTER CARE PROGRAM FOR MALE UC AGES 12 TO 17 WITH A FUNDED CAPACITY OF 48, LOCATED IN BENSON, ARIZONA. THE PROGRAM OFFERS FULL ON SITE EDUCATION, CASE CASE MANAGEMENT AND CLINICAL SERVICES. FOR THE CALENDAR YEAR OF 2022: THE PROGRAM HAS A SUCCESSFUL DISCHARGE RATE OF 100% (ALL DISCHARGES EXCEPT RUNAWAYS) TOTAL YOUTH SERVED: 420; 4 AGE REDETERMINATIONS; 1 SUCCESSFULLY TRANSFERRED TO URM PROGRAM; 411 REUNIFICATIONS; 4 TRANSFERS TO OTHER ORR PROGRAMS | social-services |
| — | DISTRICT OF COLUMBIA, GOVERNMENT OF | Department of Health and Human Services | $32,808,390 | EMERGENCY PUBLIC HEALTH RESPONSE | health |
| — | NORTHCOAST CHILDREN'S SERVICES, INC | Department of Health and Human Services | $32,763,960 | HEAD START AND EARLY HEAD START | social-services |
| — | ALBERT EINSTEIN COLLEGE OF MEDICINE | Department of Health and Human Services | $32,687,125 | CENTRAL AFRICA IEDEA | biotech |
| — | MAYO CLINIC JACKSONVILLE (A NONPROFIT CORPORATION) | Department of Health and Human Services | $32,683,845 | BIOLOGY AND PATHOBIOLOGY OF APOE IN AGING AND ALZHEIMER'S DISEASE - PROJECT SUMMARY (APOE U19: OVERALL) THE OVERARCHING GOAL OF THIS U19 PROJECT IS TO COMPREHENSIVELY UNDERSTAND THE BIOLOGY AND PATHOBIOLOGY OF APOLIPOPROTEIN E (APOE) IN AGING AND ALZHEIMER’S DISEASE (AD) TO INFORM THERAPEUTIC STRATEGIES. THE E4 ALLELE OF THE APOE GENE (APOE4) IS THE STRONGEST GENETIC RISK FACTOR FOR AD IMPACTING 50-70% OF ALL AD PATIENTS, WHILE THE E2 ALLELE IS PROTECTIVE COMPARED TO THE COMMON E3 ALLELE. APOE4 IS ALSO A STRONG RISK FACTOR FOR AGE-RELATED COGNITIVE DECLINE AND VASCULAR COGNITIVE IMPAIRMENT. TO INTEGRATE EXISTING KNOWLEDGE AND ADDRESS CRITICAL GAPS, WE PROPOSE A UNIFIED APOE CASCADE HYPOTHESIS THAT THE STRUCTURAL DIFFERENCES AND RELATED BIOCHEMICAL PROPERTIES AMONG THE THREE APOE ISOFORMS INITIATE THEIR DIFFERENTIAL EFFECTS ON A CASCADE OF EVENTS AT THE CELLULAR AND SYSTEMS LEVELS ULTIMATELY IMPACTING AGING-RELATED PATHOGENIC CONDITIONS INCLUDING AD. TOWARDS THIS, WE HAVE ASSEMBLED A MULTI-DISCIPLINARY TEAM TO SYNERGIZE EXPERTISE AND RESOURCES ACROSS MULTIPLE INSTITUTIONS. BY INTEGRATING FIVE INTERACTIVE PROJECTS AND SEVEN ROBUST CORES, WE WILL CREATE A NEXUS FOR APOE-RELATED AGING RESEARCH, SHARING THE KNOWLEDGE, EXPERTISE AND RESOURCES WITH THE BROADER SCIENTIFIC COMMUNITY. PROJECT 1 WILL WORK CLOSELY WITH CORE B TO ADDRESS THE STRUCTURAL AND BIOCHEMICAL PROPERTIES OF THE THREE APOE ISOFORMS TO GENERATE INSIGHTS FOR FUNCTIONAL OUTCOMES. PROJECTS 2, 3 AND 4 WILL INTERACTIVELY STUDY HOW APOE ISOFORMS EXPRESSED IN ASTROCYTES, MICROGLIA, OR VASCULAR MURAL CELLS IMPACT LIPID METABOLISM, GLIAL AND VASCULAR FUNCTIONS, AD-RELATED PATHOLOGIES, AND CELLULAR AND MOLECULAR PATHWAYS USING CONDITIONAL MOUSE MODELS AND SYSTEMS- BASED APPROACHES. THESE STUDIES WILL GENERATE CELL TYPE-SPECIFIC APOE/LIPOPROTEIN PARTICLES THAT WILL BE COLLECTED THROUGH IN VIVO MICRODIALYSIS FOR STRUCTURAL AND BIOCHEMICAL STUDIES. PROJECT 5 WILL CARRY OUT GENOMIC AND GENETIC ANALYSES TO IDENTIFY MODIFIERS OF APOE-RELATED AGE AT ONSET OF AD. STUDIES IN PROJECTS 2-5 WILL BE INTERACTIVELY SUPPLEMENTED BY NEUROPATHOLOGICAL STUDIES USING POSTMORTEM BRAINS FROM HEALTHY AGING STUDIES OR WITH AD PATHOLOGIES (CORE C), BIOMARKER STUDIES USING BOTH HUMAN AND MOUSE BIOSPECIMENS (CORE D), AND FUNCTIONAL STUDIES USING HUMAN IPSC-DERIVED CELLULAR AND ORGANOID MODELS (CORE E). THIS U19 PROPOSAL IS SUPPORTED BY A COMPREHENSIVE MULTI-OMICS CORE (CORE F) FOR CENTRALIZED PROTEOMICS, LIPIDOMICS, AND METABOLOMICS STUDIES ON VARIOUS ANIMAL AND IPSC MODELS, AS WELL AS HUMAN POSTMORTEM BRAINS AND FLUID BIOSPECIMENS. THE BIOINFORMATICS, BIOSTATISTICS, AND DATA MANAGEMENT CORE (CORE G) WILL PROVIDE CRITICAL SUPPORTS FOR ANALYZING LARGE DATASETS INCLUDING THOSE FROM SINGLE-CELL RNA-SEQ AND BIOSTATISTICS SUPPORTS TO ENSURE SCIENTIFIC RIGOR. CORE G WILL ALSO WORK CLOSELY WITH THE ADMINISTRATIVE CORE (CORE A) TO MAINTAIN AN APOE WEB PORTAL DESIGNATED AS EPAAD WHERE KNOWLEDGE, RESOURCES, AND DATA WILL BE SHARED WITH THE SCIENTIFIC COMMUNITY. CORE A WILL ALSO ORGANIZE ANNUAL APOE SYMPOSIUM TO PROMOTE COLLABORATION AND ENGAGE THE APOE COMMUNITY. AS SUCH, THIS U19 WILL DRIVE A TEAM-BASED EFFORT TO GENERATE ESSENTIAL KNOWLEDGE TO GUIDE DISEASE- MODIFYING THERAPIES FOR AD AND OTHER AGING-RELATED CONDITIONS. | biotech |
| — | COMMONWEALTH OF MASSACHUSETTS DEPT OF CHILDREN & FAMILIES | Department of Health and Human Services | $32,659,042 | SSBG-2024 | social-services |
| — | DIVISION OF CHILD AND FAMILY SERVICES | Department of Health and Human Services | $32,559,618 | FOSTER-2026 - FOSTER CARE | social-services |
| — | COMMUNITY HEALTH CENTER OF SNOHOMISH COUNTY | Department of Health and Human Services | $32,513,043 | HEALTH CENTER CLUSTER | health |
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