Awards/PROJECT GRANT (B)

$57,772,833

Department of Health and Human Services·National Institutes of Health

to SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE

biotechactiveONGOING · MOD OF 1996 CONTRACT

WORK BEGAN1996-12-31·LATEST ACTION2026-04-20·SOURCEUSASPENDING·SOURCE IDASST_NON_P30CA014195_075

Award description

CANCER CENTER SUPPORT GRANT

Verbatim from USAspending.gov. Capitalization, abbreviations, and codes are unchanged.

The Buildout's read

What the model surfaced from this award

Confidence: high

In plain English

Latest funding increment supporting the Salk Institute's cancer research center, operational since 1996

Sub-sectors

cancer-researchnih-grantsacademic-research

Why this matters

Salk's cancer center is among the nation's leading independent research institutions; sustained federal funding demonstrates continued U.S. commitment to academic cancer research infrastructure

Supply-chain signal

Sustains demand for specialized lab equipment, biotech reagents, computing infrastructure, and contract research services supporting cancer investigations

Generated by award_classification v2.1.0 via claude-haiku-4-5-20251001 on 2026-06-08. Cost: $0.010664.

Period of performance

Start

1996-12-31

End

2029-01-31

Status

activein 932 days

Recipient

SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE

UEI NNJ6BMBTFGN5

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Other awards from this recipient

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2026-04-20CENTER FOR MULTIOMIC HUMAN BRAIN CELL ATLAS - ABSTRACT UNDERSTANDING CELL IDENTITIES AND THEIR SPATIAL DISTRIBUTIONS THROUGHOUT DIFFERENT REGIONS OF THE HUMAN BRAIN IS A FUNDAMENTAL STEP WHEN TRYING TO INTEGRATE PHYSIOLOGICAL, BEHAVIORAL, NEUROCHEMICAL AND MOLECULAR DATA. AT PRESENT, ALTHOUGH MAJOR CATEGORIES OF THE CELL-TYPES PRESENT IN THE HUMAN BRAIN HAVE BEEN DEFINED MOLECULARLY, THE DIFFERENT SUBTYPES WITHIN THESE CATEGORIES ALONG WITH THEIR LOCATIONS ARE FAR FROM UNDERSTOOD. GENE EXPRESSION DRIVES CELL PROGRAMS AND STATES THAT UNDERLIE DISTINCT BRAIN FUNCTIONS. OPEN CHROMATIN AND MODIFIED HISTONES MARK GENE-REGULATORY ELEMENTS THAT CONTROL CELL TYPE-SPECIFIC GENE EXPRESSION PATTERNS. CYTOSINE DNA METHYLATION (MC) IS A STABLE EPIGENOMIC SIGNATURE THAT PERSISTS IN POST-MITOTIC CELLS THROUGHOUT THEIR LIFETIME, DEFINING THEIR CELLULAR IDENTITY. SINGLE-CELL GENE EXPRESSION, OPEN CHROMATIN PROFILES AND DNA METHYLATION ASSAYS HAVE BEEN SUCCESSFULLY USED TO IDENTIFY DISTINCT CELL TYPES IN AN UNBIASED FASHION IN HETEROGENEOUS TISSUES INCLUDING THE HUMAN BRAIN. THIS UM1 PROPOSAL BUILDS ON OUR EARLIER SUCCESSES IN MOUSE BRAIN MAPPING TO PRODUCE DETAILED SINGLE-CELL MULTIMOMIC AND SPATIAL CELL MAPS AT THE SINGLE-CELL LEVEL ACROSS 100 ANATOMICALLY DEFINED REGIONS IN THE HUMAN BRAIN. PROFILING HUMAN BRAIN SAMPLES WILL PERMIT THE DISCOVERY OF UNIQUE GENE EXPRESSION PATTERNS FOR EACH MOLECULARLY-DEFINED CELL TYPE, IDENTIFY THEIR SPATIAL ORGANIZATION, AND THEIR SPECIFIC NON-CODING DNA REGULATORY REGIONS. MULTI-MODAL INTEGRATION BETWEEN EPIGENOMIC AND TRANSCRIPTOMIC SIGNATURES WILL ALLOW THE IDENTIFICATION OF NEW CELL TYPES AND UNIQUE CELL-TYPE MARKERS THAT WILL RAPIDLY BE MADE AVAILABLE TO THE ENTIRE COMMUNITY. THIS UM1 PROJECT WILL ALSO PROVIDE NEW TOOLS FOR GENETIC ACCESS OF PREVIOUSLY INACCESSIBLE BRAIN REGIONS AS WELL AS FACILITATE THE FUNCTIONAL ANALYSIS OF GENETIC VARIANTS ASSOCIATED WITH NEUROPSYCHIATRIC AND NEUROLOGICAL DISORDERS.$74.8M

Sources

USAspending.gov — all awards for this UEI →
SAM.gov entity registration →
Award record ingested from usaspending. Source identifier ASST_NON_P30CA014195_075.

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