Awards/PROJECT GRANT (B)

$56,826,924

Department of Health and Human Services·National Institutes of Health

to UNIVERSITY OF WISCONSIN SYSTEM

biotechactiveONGOING · MOD OF 2018 CONTRACT

WORK BEGAN2018-09-15·LATEST ACTION2026-04-06·SOURCEUSASPENDING·SOURCE IDASST_NON_R01AG060737_075

Award description

WISCONSIN LONGITUDINAL STUDY - INITIAL LIFETIME'S IMPACT ON ALZHEIMER'S DISEASE AND RELATED DEMENTIAS (WLS-ILIAD STUDY)

Verbatim from USAspending.gov. Capitalization, abbreviations, and codes are unchanged.

The Buildout's read

What the model surfaced from this award

Confidence: high

In plain English

Funds the Wisconsin Longitudinal Study investigating lifetime factors influencing Alzheimer's disease and related dementias.

Sub-sectors

nih-research-grantalzheimers-dementialongitudinal-study

Why this matters

Addresses dementia prevention and early intervention through long-term epidemiological research, critical as aging populations drive disease burden.

Supply-chain signal

Supports academic research infrastructure and biomarker analysis capabilities at University of Wisconsin System institutions.

U.S.–China competition angle

Strengthens U.S. neuroscience research capacity in dementia, an area of global biomedical competition and aging-society relevance.

Generated by award_classification v2.0.0 via claude-haiku-4-5-20251001 on 2026-05-15. Cost: $0.002226.

Period of performance

Start

2018-09-15

End

2028-02-29

Status

activein 652 days

Recipient

UNIVERSITY OF WISCONSIN SYSTEM

UEI LCLSJAGTNZQ7

View full profile →

Other awards from this recipient

See all →

—CHILDHOOD ASTHMA IN URBAN SETTINGS CLINICAL RESEARCH NETWORK - LEADERSHIP CENTER - PROJECT SUMMARY/ABSTRACT THE OVERALL GOALS OF OUR CHILDHOOD ASTHMA IN URBAN SETTINGS (CAUSE)-LEADERSHIP CENTER PROPOSAL ARE TO PROVIDE ADMINISTRATIVE LEADERSHIP AND SUPPORT TO DEVELOP AND CONDUCT COLLABORATIVE RESEARCH TO ADDRESS HIGH PRIORITY UNMET NEEDS FOR CHILDHOOD ASTHMA IN URBAN COMMUNITIES, INCLUDING: A) DEVELOPING STRATEGIES TO PREVENT ASTHMA, B) IMPROVING TREATMENT AND INHIBITING PROGRESSION, C) REDUCING SEVERE EXACERBATIONS, AND D) DEFINING ENDOTYPES OF RESPIRATORY HEALTH AND DISEASE. FOUR HYPOTHESES ARE PROPOSED TO ACCOMPLISH THESE GOALS. FIRST, SUPPLEMENTATION WITH IMMUNE MODULATING BACTERIA IN INFANCY WILL PREVENT THE EARLY LIFE PERTURBATIONS IN THE GUT MICROBIOME THAT HAVE BEEN ASSOCIATED WITH RISK FOR THE DEVELOPMENT OF ALLERGIC SENSITIZATION AND ASTHMA, AND WILL PROMOTE AIRWAY MUCOSAL IMMUNE DEVELOPMENT. SECOND, GIVEN THE IMPORTANCE OF COCKROACH (CR) ALLERGY AND EXPOSURE TO ASTHMA MORBIDITY IN URBAN CHILDREN, CR IMMUNOTHERAPY WILL IMPROVE ASTHMA CONTROL AND REDUCE DISEASE PROGRESSION. THIRD, WE PROPOSE THAT TRANSCRIPTIONAL ANALYSIS OF AIRWAY CELLS WILL DEFINE T2-LOW MECHANISMS THAT CONTRIBUTE TO BOTH NON-ATOPIC AND ATOPIC ASTHMA AND PROVIDE NEW INSIGHTS INTO TREATMENT. FINALLY, MULTI-OMICS EVALUATION OF AIRWAY CELLS AND SECRETIONS OBTAINED DURING SEVERE EXACERBATIONS LEADING TO ED VISITS AND HOSPITALIZATIONS WILL REVEAL NOVEL MECHANISTIC PATHWAYS TO INFORM IMPROVED TREATMENT AND PREVENTION. WE PROPOSE FIVE PROTOCOLS TO TEST THESE HYPOTHESES: 1. URBAN ENVIRONMENT AND CHILDHOOD ASTHMA STUDY (URECA) 2. EFFECTS OF A MICROBIAL SUPPLEMENT (STMC-103H) ON MICROBIAL COLONIZATION AND IMMUNE DEVELOPMENT 3. COCKROACH (CR) IMMUNOTHERAPY (IT) IN URBAN CHILDREN WITH MODERATE-SEVERE ASTHMA PROTECTED BY OMALIZUMAB 4. PATHOGENESIS AND MECHANISMS OF T2-LOW (NON-ATOPIC) ASTHMA 5. SEVERE ASTHMA EXACERBATIONS IN THE EMERGENCY DEPARTMENT (ED) AND HOSPITAL: IDENTIFYING TARGETS FOR PREVENTION AND TREATMENT IT IS OUR EXPECTATION THAT OUR PROPOSED CAUSE RESEARCH PROGRAM WILL PROVIDE CRITICAL INFORMATION NEEDED TO RECOGNIZE ASTHMA PHENOTYPES AND ENDOTYPES IN URBAN CHILDREN, IMPROVE TREATMENT OF ASTHMA AND ESTABLISH DIRECTION FOR PREVENTION. COLLECTIVELY, THESE STUDIES WILL CONTINUE THE RIGOROUS PROGRAMMATIC APPROACH OF THE NIAID ASTHMA NETWORKS TOWARDS ACHIEVING THE LONG-TERM GOALS OF DISEASE MODIFICATION AND PREVENTION OF DISEASE IN HIGH-RISK CHILDREN OF LOW-INCOME FAMILIES LIVING IN URBAN COMMUNITIES.$40.9M

Sources

USAspending.gov — all awards for this UEI →
SAM.gov entity registration →
Award record ingested from usaspending. Source identifier ASST_NON_R01AG060737_075.

The Buildout does not edit federal records. Any inaccuracy reflects the upstream source; it will update here when corrected there.